Structure-Function Analysis of Global Pharmaceutical Linkage Regulations

The Structure–Function Linkage Database

The Structure-Function Linkage Database (SFLD, http://sfld.rbvi.ucsf.edu/) is a manually curated classification resource describing structure-function relationships for functionally diverse enzyme superfamilies. Members of such superfamilies are diverse in their overall reactions yet share a common ancestor and some conserved active site features associated with conserved functional attributes ...

Pharmaceutical regulations in India: the missing links

Introduction Modern pharmaceutical industry in India emerged in the 1900s and with that regulation of pharmaceuticals also evolved. The reforms of the 90s while improving the exports, also brought in improved standards of quality to be followed in the entire supply chain of drugs. While for the manufacturers it meant documentation, increased expenditure, and more export opportunities, for the c...

[Challenges to new regulations of pharmaceutical products in Peru].

Leveraging enzyme structure-function relationships for functional inference and experimental design: the structure-function linkage database.

The study of mechanistically diverse enzyme superfamilies-collections of enzymes that perform different overall reactions but share both a common fold and a distinct mechanistic step performed by key conserved residues-helps elucidate the structure-function relationships of enzymes. We have developed a resource, the structure-function linkage database (SFLD), to analyze these structure-function...

Economic linkage impacts of Hawaii’s longline fishing regulations

Fisheries regulations driven by environmental concerns would not only directly affect fisheries sectors but also tend to indirectly influence other sectors through intersectoral input–output linkages. This paper examines both backward and forward linkages of Hawaii’s fisheries sectors to the rest of the economy, and based on this evaluates the potential economic impacts of longline fishing regu...